Tuesday, August 28, 2012

Meth History Cont.


  • 1938: First published report of amphetamine addition and psychosis
  • 1940: “Methedrine” commercial trade name for methamphetamine
  • Both amphetamine and methamphetamine used as performance
    enhancer by Japanese, German and Americans in WWII. Led to
    addiction problems in Japanese after the war.
  • 1950-53: amphetamine distributed to US troops in Korean war
  • 1951: U.S. Congress passes a law requiring prescriptions for all oral
    and injectable amphetamines used commonly to treat obesity,
    narcolepsy and depression.
  • 1954: Height of Japanese addiction: 2 million users in 88.5 million
    population
  • 1959: first report of IV injection of contents of benzedrine inhaler.
    OTC Benzedrine Inhalers within drawn from market. OTC
    Methedrine inhalers offered.
  • 1962: early reports of illicit domestic production by biker gangs
  • 1965: OTC Methedrine inhalers withdrawn from market. 31 million
    prescriptions written: mostly to women.
  • Amphetamine and methamphetamine become Schedule II drugs in
    1971
  • 1970-80s cocaine drug of choice until it gets too pricey. People turn to
    speed as a substitute
  • Motorcycle gangs synthesized drug using phenyl-2-propanone until
    late 1980’s. P2P became restricted substance, so chemistry shifted to
    making P2P from phenyl acetic acid or other ways
  • 1987, DEA busts first HI/Red Phosphorus lab in the country in
    California. This method has a higher yield and more potent
    methamphetamine. Mexican nationals take over the market from biker
    gangs with this method.
  • 1990s: Mexican “Super labs” produce pounds of meth from chemicals
    obtained overseas and smuggled across border. Illegal aliens make
    the meth in well-organized discreet segments in the Central Valley of
    CA.
  • Current methods (Iodine/Red P or Lithium/Ammonia) using
    pseudoephedrine became popular as other chemicals became illegal     
 Current Method 
 Reducing
  ephedrine/pseudoephedrine to
methamphetamine
  • Iodine-red phosphorus
  • Ammonia-lithium (Nazi method)    
      Old Methods
  •   Reductive Amination of Phenyl-2-propanone with Aluminum amalgam 

  •  Reducing ephedrine/pseudoephedrine to methamphetamine via Catalytic hydrogenation
 
I. HI/Red Phosphorus Reduction



Ephedrine

 Natural source: ephedra sinica (source: dried stem)
Stereochemistry: 2 chiral center= 4 forms
  • d,l ephedrine
  • d,l pseudoephedrine (OH and NH on same side)
l-ephedrine, d-pseudoephedrine produce dmethamphetamine
 Ephedrine used as bronchodilator;
pseudoephedrine used as decongestant
                             


       
                                                                       












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